VISA-A pass to innate immunity

Bao Chang Qi, Yue Huang, Dominic Rowe, Glenda Halliday*

*Corresponding author for this work

Research output: Contribution to journalShort survey

18 Citations (Scopus)

Abstract

Virus-induced signaling adaptor (VISA) is essential for host innate immune responses against double-stranded RNA viral infection and viral replication. It is an adaptor that activates the transcription factors nuclear factor κB (NF-κB) and interferon regulatory factor 3 (IRF3) that regulate the expression of type I interferons. The localization of VISA to the outer membrane of mitochondria and the cellular consequences of its activation implicate this protein in the cellular etiology of neurodegenerative disorders.

Original languageEnglish
Pages (from-to)287-291
Number of pages5
JournalInternational Journal of Biochemistry and Cell Biology
Volume39
Issue number2
DOIs
Publication statusPublished - 2007
Externally publishedYes

Keywords

  • Mitochondria
  • Neurodegenerative disorders
  • Viral infection
  • VISA

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