VISA-A pass to innate immunity

Bao Chang Qi; Yue Huang; Dominic Rowe; Glenda Halliday

doi:10.1016/j.biocel.2006.08.016

VISA-A pass to innate immunity

Bao Chang Qi, Yue Huang, Dominic Rowe, Glenda Halliday^*

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

18 Citations (Scopus)

Abstract

Virus-induced signaling adaptor (VISA) is essential for host innate immune responses against double-stranded RNA viral infection and viral replication. It is an adaptor that activates the transcription factors nuclear factor κB (NF-κB) and interferon regulatory factor 3 (IRF3) that regulate the expression of type I interferons. The localization of VISA to the outer membrane of mitochondria and the cellular consequences of its activation implicate this protein in the cellular etiology of neurodegenerative disorders.

Original language	English
Pages (from-to)	287-291
Number of pages	5
Journal	International Journal of Biochemistry and Cell Biology
Volume	39
Issue number	2
DOIs	https://doi.org/10.1016/j.biocel.2006.08.016
Publication status	Published - 2007
Externally published	Yes

Keywords

Mitochondria
Neurodegenerative disorders
Viral infection
VISA

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10.1016/j.biocel.2006.08.016

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title = "VISA-A pass to innate immunity",

abstract = "Virus-induced signaling adaptor (VISA) is essential for host innate immune responses against double-stranded RNA viral infection and viral replication. It is an adaptor that activates the transcription factors nuclear factor κB (NF-κB) and interferon regulatory factor 3 (IRF3) that regulate the expression of type I interferons. The localization of VISA to the outer membrane of mitochondria and the cellular consequences of its activation implicate this protein in the cellular etiology of neurodegenerative disorders.",

keywords = "Mitochondria, Neurodegenerative disorders, Viral infection, VISA",

author = "Qi, {Bao Chang} and Yue Huang and Dominic Rowe and Glenda Halliday",

year = "2007",

doi = "10.1016/j.biocel.2006.08.016",

language = "English",

volume = "39",

pages = "287--291",

journal = "International Journal of Biochemistry and Cell Biology",

issn = "1357-2725",

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T1 - VISA-A pass to innate immunity

AU - Qi, Bao Chang

AU - Huang, Yue

AU - Rowe, Dominic

AU - Halliday, Glenda

PY - 2007

Y1 - 2007

N2 - Virus-induced signaling adaptor (VISA) is essential for host innate immune responses against double-stranded RNA viral infection and viral replication. It is an adaptor that activates the transcription factors nuclear factor κB (NF-κB) and interferon regulatory factor 3 (IRF3) that regulate the expression of type I interferons. The localization of VISA to the outer membrane of mitochondria and the cellular consequences of its activation implicate this protein in the cellular etiology of neurodegenerative disorders.

AB - Virus-induced signaling adaptor (VISA) is essential for host innate immune responses against double-stranded RNA viral infection and viral replication. It is an adaptor that activates the transcription factors nuclear factor κB (NF-κB) and interferon regulatory factor 3 (IRF3) that regulate the expression of type I interferons. The localization of VISA to the outer membrane of mitochondria and the cellular consequences of its activation implicate this protein in the cellular etiology of neurodegenerative disorders.

KW - Mitochondria

KW - Neurodegenerative disorders

KW - Viral infection

KW - VISA

UR - http://www.scopus.com/inward/record.url?scp=33845186551&partnerID=8YFLogxK

U2 - 10.1016/j.biocel.2006.08.016

DO - 10.1016/j.biocel.2006.08.016

M3 - Short survey

C2 - 17029998

AN - SCOPUS:33845186551

SN - 1357-2725

VL - 39

SP - 287

EP - 291

JO - International Journal of Biochemistry and Cell Biology

JF - International Journal of Biochemistry and Cell Biology

IS - 2

ER -

VISA-A pass to innate immunity

Abstract

Keywords

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