Visual rehabilitation rate after isolated descemet membrane transplantation

Descemet membrane endothelial keratoplasty

Lisanne Ham, Chandra Balachandran, Christianne A. Verschoor, Jacqueline Van Der Wees, Gerrit R J Melles

Research output: Contribution to journalArticle

114 Citations (Scopus)


Objective: To evaluate visual rehabilitation after Descemet membrane endothelial keratoplasty (DMEK) in the management of corneal endothelial disorders. Methods: In this prospective, nonrandomized, clinical study, DMEK was performed in a first group of 35 consecutive patients with either Fuchs endothelial dystrophy or bullous keratopathy. The Descemet membrane was stripped from the recipient posterior stroma with the anterior chamber completely filled with air. Using a 3.0-mm clear corneal incision, an organ-cultured donor Descemet roll 9 to 10 mm in diameter was inserted into the recipient anterior chamber, positioned on the posterior stroma, and secured by completely filling the anterior chamber with air for 45 to 60 minutes. Results: Ten eyes had preexisting ocular disease or an early graft detachment. In the remaining 25 DMEK-treated eyes, best-corrected visual acuity was 20/40 (Snellen notation, 0.5) or more in 18 eyes (72%) within 1 month. At 3 months, best-corrected visual acuity was 20/40 (0.5) or more in 23 of 25 eyes (92%) and 20/25 (0.8) or more in 15 of 25 eyes (60%). Conclusions: In most cases, DMEK results in functional visual rehabilitation within 1 to 3 months. Overall, visual recovery after DMEK may be faster and more complete than with other techniques for (lamellar) keratoplasty for treatment of corneal endothelial disorders. Trial Registration: Identifier: NCT00521898.

Original languageEnglish
Pages (from-to)252-255
Number of pages4
JournalArchives of Ophthalmology
Issue number3
Publication statusPublished - Mar 2009
Externally publishedYes

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