Visualization of upconverting nanoparticles in strongly scattering media

E. V. Khaydukov, V. A. Semchishen, V. N. Seminogov, A. V. Nechaev, A. V. Zvyagin, V. I. Sokolov, A. S. Akhmanov, V. Ya Panchenko

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Optical visualization systems are needed in medical applications for determining the localization of deep-seated luminescent markers in biotissues. The spatial resolution of such systems is limited by the scattering of the tissues. We present a novel epi-luminescent technique, which allows a 1.8-fold increase in the lateral spatial resolution in determining the localization of markers lying deep in a scattering medium compared to the traditional visualization techniques. This goal is attained by using NaYF4:Yb3+Tm3+@NaYF4 core/shell nanoparticles and special optical fiber probe with combined channels for the excitation and detection of anti-Stokes luminescence signals.

Original languageEnglish
Pages (from-to)1952-1964
Number of pages13
JournalBiomedical Optics Express
Volume5
Issue number6
DOIs
Publication statusPublished - 28 May 2014
Externally publishedYes

Keywords

  • imaging through turbid media
  • nanomaterials

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  • Cite this

    Khaydukov, E. V., Semchishen, V. A., Seminogov, V. N., Nechaev, A. V., Zvyagin, A. V., Sokolov, V. I., ... Panchenko, V. Y. (2014). Visualization of upconverting nanoparticles in strongly scattering media. Biomedical Optics Express, 5(6), 1952-1964. https://doi.org/10.1364/BOE.5.001952