Visualization of upconverting nanoparticles in strongly scattering media

E. V. Khaydukov; V. A. Semchishen; V. N. Seminogov; A. V. Nechaev; A. V. Zvyagin; V. I. Sokolov; A. S. Akhmanov; V. Ya Panchenko

doi:10.1364/BOE.5.001952

Visualization of upconverting nanoparticles in strongly scattering media

E. V. Khaydukov, V. A. Semchishen, V. N. Seminogov, A. V. Nechaev, A. V. Zvyagin, V. I. Sokolov, A. S. Akhmanov, V. Ya Panchenko

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Optical visualization systems are needed in medical applications for determining the localization of deep-seated luminescent markers in biotissues. The spatial resolution of such systems is limited by the scattering of the tissues. We present a novel epi-luminescent technique, which allows a 1.8-fold increase in the lateral spatial resolution in determining the localization of markers lying deep in a scattering medium compared to the traditional visualization techniques. This goal is attained by using NaYF₄:Yb³⁺Tm³⁺@NaYF₄ core/shell nanoparticles and special optical fiber probe with combined channels for the excitation and detection of anti-Stokes luminescence signals.

Original language	English
Pages (from-to)	1952-1964
Number of pages	13
Journal	Biomedical Optics Express
Volume	5
Issue number	6
DOIs	https://doi.org/10.1364/BOE.5.001952
Publication status	Published - 1 Jun 2014
Externally published	Yes

Keywords

imaging through turbid media
nanomaterials

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10.1364/BOE.5.001952

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title = "Visualization of upconverting nanoparticles in strongly scattering media",

abstract = "Optical visualization systems are needed in medical applications for determining the localization of deep-seated luminescent markers in biotissues. The spatial resolution of such systems is limited by the scattering of the tissues. We present a novel epi-luminescent technique, which allows a 1.8-fold increase in the lateral spatial resolution in determining the localization of markers lying deep in a scattering medium compared to the traditional visualization techniques. This goal is attained by using NaYF4:Yb3+Tm3+@NaYF4 core/shell nanoparticles and special optical fiber probe with combined channels for the excitation and detection of anti-Stokes luminescence signals.",

keywords = "imaging through turbid media, nanomaterials",

author = "Khaydukov, {E. V.} and Semchishen, {V. A.} and Seminogov, {V. N.} and Nechaev, {A. V.} and Zvyagin, {A. V.} and Sokolov, {V. I.} and Akhmanov, {A. S.} and Panchenko, {V. Ya}",

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doi = "10.1364/BOE.5.001952",

language = "English",

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T1 - Visualization of upconverting nanoparticles in strongly scattering media

AU - Khaydukov, E. V.

AU - Semchishen, V. A.

AU - Seminogov, V. N.

AU - Nechaev, A. V.

AU - Zvyagin, A. V.

AU - Sokolov, V. I.

AU - Akhmanov, A. S.

AU - Panchenko, V. Ya

PY - 2014/6/1

Y1 - 2014/6/1

N2 - Optical visualization systems are needed in medical applications for determining the localization of deep-seated luminescent markers in biotissues. The spatial resolution of such systems is limited by the scattering of the tissues. We present a novel epi-luminescent technique, which allows a 1.8-fold increase in the lateral spatial resolution in determining the localization of markers lying deep in a scattering medium compared to the traditional visualization techniques. This goal is attained by using NaYF4:Yb3+Tm3+@NaYF4 core/shell nanoparticles and special optical fiber probe with combined channels for the excitation and detection of anti-Stokes luminescence signals.

AB - Optical visualization systems are needed in medical applications for determining the localization of deep-seated luminescent markers in biotissues. The spatial resolution of such systems is limited by the scattering of the tissues. We present a novel epi-luminescent technique, which allows a 1.8-fold increase in the lateral spatial resolution in determining the localization of markers lying deep in a scattering medium compared to the traditional visualization techniques. This goal is attained by using NaYF4:Yb3+Tm3+@NaYF4 core/shell nanoparticles and special optical fiber probe with combined channels for the excitation and detection of anti-Stokes luminescence signals.

KW - imaging through turbid media

KW - nanomaterials

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DO - 10.1364/BOE.5.001952

M3 - Article

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VL - 5

SP - 1952

EP - 1964

JO - Biomedical Optics Express

JF - Biomedical Optics Express

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ER -

Visualization of upconverting nanoparticles in strongly scattering media

Abstract

Keywords

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