Vitamin B12 deficiency associated with symptoms of frontotemporal dementia

C. Blundo*, D. Marin, M. Ricci

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)

    Abstract

    We report the case of an elderly patient with cobalamin deficiency who progressively developed cognitive and behavioral symptoms associated with neuropsychiatric disturbances. His neuropsychological profile showed many features suggestive for a frontal-dysexecutive syndrome and was related to a predominant asymmetric (right > left) frontal lobe hypoperfusion. He completely recovered after a treatment with vitamin B12 and follow-up of 7 years showed that his improvement remained stable. Along with the other cases reported in the literature, our case also proves that there are some cases of vitamin B12 deficiency that can manifest with the symptoms of frontotemporal dementia and that they are completely reversible after substitution therapy.

    Original languageEnglish
    Pages (from-to)101-105
    Number of pages5
    JournalNeurological Sciences
    Volume32
    Issue number1
    DOIs
    Publication statusPublished - Feb 2011

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