Vitamin D recommendations in clinical guidelines: a systematic review, quality evaluation and analysis of potential predictors

David Fraile Navarro*, Alberto López García- Franco, Ena Niño de Guzmán, Montserrat Rabassa, Rocío Zamanillo Campos, Héctor Pardo- Hernández, Ignacio Ricci-Cabello, Carlos Canelo- Aybar, Jose F. Meneses-Echavez, Juan José Yepes-Nuñez, Jesse Kuindersma, Ignasi Gich Saladich, Pablo Alonso-Coello

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)


Background: Vitamin D has been widely promoted for bone health through supplementation and fortification of the general adult population. However, there is growing evidence that does not support these strategies. Our aim is to review the quality and recommendations on vitamin D nutritional and clinical practice guidelines and to explore predictive factors for their direction and strength. Methods: We searched three databases and two guideline repositories from 2010 onwards. We performed a descriptive analysis, a quality appraisal using AGREE II scores (Appraisal of Guidelines Research and Evaluation) and a bivariate analysis evaluating the association between direction and strength of recommendations, AGREE II domains' scores and pre-specified characteristics. Results: We included 34 guidelines, 44.1% recommended, 26.5% suggested and 29.4% did not recommend vitamin D supplementation. Guidelines that scored higher for "editorial independence" and "overall quality score" were less likely to recommend or suggest vitamin D supplementation (median 68.8 vs 35.4; P = .001 and 58.3 vs 37.5; P = .02). Guidance produced by government organisations and those that reported source of funding were associated with higher AGREE II scores. Unclear role of source of funding was associated with recommending or suggesting vitamin D supplementation (P = .034). Editorial independence was an independent predictor for recommending or suggesting vitamin D supplementation (OR 1.09; CI95% 1.02 to 1.16; P = .006). Conclusions: Policymakers, clinicians and patients should be aware that lower quality guidelines and those reporting conflicts of interest are more likely to promote vitamin D supplementation. Guideline organisations should improve the quality of their recommendations' development and the management of conflicts of interest. Users and editors should be aware of these findings when using and appraising guidelines.
Original languageEnglish
Article numbere14805
Pages (from-to)1-21
Number of pages21
JournalInternational Journal of Clinical Practice
Issue number11
Early online date6 Sept 2021
Publication statusPublished - Nov 2021


  • guidelines
  • primary care
  • public health
  • quality appraisal
  • Vitamin D


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