Vitamin E content and low density lipoprotein oxidizability induced by free radicals

A. V. Babiy; J. M. Gebicki; D. R. Sullivan

doi:10.1016/0021-9150(90)90064-P

Vitamin E content and low density lipoprotein oxidizability induced by free radicals

A. V. Babiy, J. M. Gebicki^*, D. R. Sullivan

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

123 Citations (Scopus)

Abstract

Human LDL, HDL and lipoprotein deficient plasma isolated from 15 normal subjects was exposed to oxygen free radicals generated by gamma rays and the formation of peroxides and changes in levels of LDL α-tocopherol were measured. LDL exhibited an initial resistance against oxidation stress when compared to HDL. The results obtained for different individuals showed that there was no correlation between the initial levels of vitamin E in LDL or plasma and the amount of peroxide formed after exposure of the LDL to a standard quantity of oxygen radicals. Kinetic experiments with original LDL and LDL containing incorporated a-tocopherol demonstrated that the vitamin performed its antioxidant role by conferring some early protection to the lipids, being consumed in the process, but it was clear that additional factors are also instrumental in determining the total antioxidant potential of the human LDL.

Original language	English
Pages (from-to)	175-182
Number of pages	8
Journal	Atherosclerosis
Volume	81
Issue number	3
DOIs	https://doi.org/10.1016/0021-9150(90)90064-P
Publication status	Published - 1990

Keywords

LDL peroxide
Tri-iodide
Vitamin E

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10.1016/0021-9150(90)90064-P

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title = "Vitamin E content and low density lipoprotein oxidizability induced by free radicals",

abstract = "Human LDL, HDL and lipoprotein deficient plasma isolated from 15 normal subjects was exposed to oxygen free radicals generated by gamma rays and the formation of peroxides and changes in levels of LDL α-tocopherol were measured. LDL exhibited an initial resistance against oxidation stress when compared to HDL. The results obtained for different individuals showed that there was no correlation between the initial levels of vitamin E in LDL or plasma and the amount of peroxide formed after exposure of the LDL to a standard quantity of oxygen radicals. Kinetic experiments with original LDL and LDL containing incorporated a-tocopherol demonstrated that the vitamin performed its antioxidant role by conferring some early protection to the lipids, being consumed in the process, but it was clear that additional factors are also instrumental in determining the total antioxidant potential of the human LDL.",

keywords = "LDL peroxide, Tri-iodide, Vitamin E",

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T1 - Vitamin E content and low density lipoprotein oxidizability induced by free radicals

AU - Babiy, A. V.

AU - Gebicki, J. M.

AU - Sullivan, D. R.

PY - 1990

Y1 - 1990

N2 - Human LDL, HDL and lipoprotein deficient plasma isolated from 15 normal subjects was exposed to oxygen free radicals generated by gamma rays and the formation of peroxides and changes in levels of LDL α-tocopherol were measured. LDL exhibited an initial resistance against oxidation stress when compared to HDL. The results obtained for different individuals showed that there was no correlation between the initial levels of vitamin E in LDL or plasma and the amount of peroxide formed after exposure of the LDL to a standard quantity of oxygen radicals. Kinetic experiments with original LDL and LDL containing incorporated a-tocopherol demonstrated that the vitamin performed its antioxidant role by conferring some early protection to the lipids, being consumed in the process, but it was clear that additional factors are also instrumental in determining the total antioxidant potential of the human LDL.

AB - Human LDL, HDL and lipoprotein deficient plasma isolated from 15 normal subjects was exposed to oxygen free radicals generated by gamma rays and the formation of peroxides and changes in levels of LDL α-tocopherol were measured. LDL exhibited an initial resistance against oxidation stress when compared to HDL. The results obtained for different individuals showed that there was no correlation between the initial levels of vitamin E in LDL or plasma and the amount of peroxide formed after exposure of the LDL to a standard quantity of oxygen radicals. Kinetic experiments with original LDL and LDL containing incorporated a-tocopherol demonstrated that the vitamin performed its antioxidant role by conferring some early protection to the lipids, being consumed in the process, but it was clear that additional factors are also instrumental in determining the total antioxidant potential of the human LDL.

KW - LDL peroxide

KW - Tri-iodide

KW - Vitamin E

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U2 - 10.1016/0021-9150(90)90064-P

DO - 10.1016/0021-9150(90)90064-P

M3 - Article

C2 - 2350369

AN - SCOPUS:0025213132

VL - 81

SP - 175

EP - 182

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 3

ER -

Vitamin E content and low density lipoprotein oxidizability induced by free radicals

Abstract

Keywords

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