TY - JOUR
T1 - Wearable corneal biosensors fabricated from PEDOT functionalized sulfur-doped graphene for use in the early detection of myopia
AU - Zhang, Wenjing
AU - Dong, Gongxian
AU - Feng, Haihua
AU - Shan, Suyan
AU - Huang, Libin
AU - Yuan, Feng
AU - Bao, Bijun
AU - Yan, Lu
AU - Xia, Zhaolin
AU - Lawson, Tom
AU - Chen, Jun
AU - Qu, Jia
AU - Liu, Yong
PY - 2020/12
Y1 - 2020/12
N2 - Myopia is an irreversible visual disorder. Its pathogenic mechanism is not completely determined. This lack of understanding has led to difficulties in its early detection and prevention. Herein, it is reported that the content of dopamine (DA) inside tears is related to myopia diopter. Changes in DA are detected by the use of a wearable corneal biosensor. The biosensor is prepared by electrodeposition of the enzyme tyrosinase and poly (3,4-ethylenedioxythiophene) functionalized sulfur-doped graphene onto a self-designed corneal microelectrode. This leads to a high-performance biosensor with a high sensitivity (of 12.9 µA × 10−3 m−1 cm−2), a good detection limit (of 101 × 10−9 m), excellent selectivity, and long-term stability. In vivo sensing tests on rabbits confirm a linear relationship between DA added to the animal eyes and the current response of the biosensor. Further tests on human tears sourced from defocus-induced myopia patients who have various myopia diopters show that the biosensor outputted a sensitive current signal that is related to the number of myopia diopters. This suggests there is an underlying relationship between myopia diopters and DA content in tears. It may provide a novel approach to a better understanding of myopia formation and its prevention.
AB - Myopia is an irreversible visual disorder. Its pathogenic mechanism is not completely determined. This lack of understanding has led to difficulties in its early detection and prevention. Herein, it is reported that the content of dopamine (DA) inside tears is related to myopia diopter. Changes in DA are detected by the use of a wearable corneal biosensor. The biosensor is prepared by electrodeposition of the enzyme tyrosinase and poly (3,4-ethylenedioxythiophene) functionalized sulfur-doped graphene onto a self-designed corneal microelectrode. This leads to a high-performance biosensor with a high sensitivity (of 12.9 µA × 10−3 m−1 cm−2), a good detection limit (of 101 × 10−9 m), excellent selectivity, and long-term stability. In vivo sensing tests on rabbits confirm a linear relationship between DA added to the animal eyes and the current response of the biosensor. Further tests on human tears sourced from defocus-induced myopia patients who have various myopia diopters show that the biosensor outputted a sensitive current signal that is related to the number of myopia diopters. This suggests there is an underlying relationship between myopia diopters and DA content in tears. It may provide a novel approach to a better understanding of myopia formation and its prevention.
KW - dopamine (DA)
KW - myopia
KW - poly (3,4-ethylenedioxythiophene) (PEDOT)
KW - sulfur-doped graphene
KW - wearable corneal biosensors
UR - http://www.scopus.com/inward/record.url?scp=85096700419&partnerID=8YFLogxK
UR - http://purl.org/au-research/grants/arc/CE140100003
U2 - 10.1002/admt.202000682
DO - 10.1002/admt.202000682
M3 - Article
AN - SCOPUS:85096700419
SN - 2365-709X
VL - 5
SP - 1
EP - 7
JO - Advanced Materials Technologies
JF - Advanced Materials Technologies
IS - 12
M1 - 2000682
ER -