When does curatively treated colorectal cancer recur?

An Australian perspective

Mifanwy M. Reece*, Pierre H. Chapuis, Anil Keshava, Peter Stewart, Michael Suen, Matthew J. F. X. Rickard

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: While most colorectal cancer (CRC) recurrences reportedly occur within 3 years following curative treatment, many studies are limited by short-term follow-up. This study examines the time to recurrence of CRC in a large Australian cohort with a long follow-up period and assesses whether time to recurrence has changed over time. Methods: A comprehensive prospective database of patients undergoing resection for CRC is maintained at Concord Hospital, Sydney. Demographic and time to recurrence data were extracted for patients who developed a recurrence following potentially curative resection for colon cancer from 1995 to 2010 and rectal cancer from 1971 to 2010. Non-deceased patients had a minimum of 5 years follow-up. Results: Between 1995 and 2010, 2575 patients with CRC underwent surgery. After exclusions, 386 had recurrence following potentially curative resection, ranging from 1 to 172.5 months (median 20.3) after treatment. Within 1 year, 27.5% recurred, 57.5% by 2 years, 74.6% by 3 years, 85.5% by 4 years and 89.6% by 5 years. There was no difference in time to recurrence between colon and rectal cancers (P = 0.674). Among patients having a potentially curative resection for rectal cancer between 1971 and 2010, 386 recurred. There was no difference in time to recurrence by decade (P = 0.863). Conclusion: The majority of recurrences occurred within 3 years of curative treatment. Had surveillance been limited to 5 years, detection of more than 10% of recurrences would have been delayed. Time to recurrence for rectal cancer has not changed in over 40 years, despite treatment advances.

Original languageEnglish
Pages (from-to)1163-1167
Number of pages5
JournalANZ Journal of Surgery
Volume88
Issue number11
DOIs
Publication statusPublished - 1 Nov 2018
Externally publishedYes

Keywords

  • colorectal cancer
  • recurrence
  • surveillance

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    Reece, M. M., Chapuis, P. H., Keshava, A., Stewart, P., Suen, M., & Rickard, M. J. F. X. (2018). When does curatively treated colorectal cancer recur? An Australian perspective. ANZ Journal of Surgery, 88(11), 1163-1167. https://doi.org/10.1111/ans.14870