Whole genome sequence analysis of Shigella from Malawi identifies fluoroquinolone resistance

George E. Stenhouse; Khuzwayo C. Jere; Chikondi Peno; Rebecca J. Bengtsson; End Chinyama; Jonathan Mandolo; Amy Cain; Miren Iturriza-Gómara; Naor Bar-Zeev; Nigel A. Cunliffe; Jennifer Cornick; Kate S. Baker

doi:10.1099/mgen.0.000532

Whole genome sequence analysis of Shigella from Malawi identifies fluoroquinolone resistance

George E. Stenhouse, Khuzwayo C. Jere, Chikondi Peno, Rebecca J. Bengtsson, End Chinyama, Jonathan Mandolo, Amy Cain, Miren Iturriza-Gómara, Naor Bar-Zeev, Nigel A. Cunliffe, Jennifer Cornick, Kate S. Baker^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

40 Downloads (Pure)

Abstract

Increasing antimicrobial resistance and limited alternative treatments have led to fluoroquinolone-resistant Shigella strain inclusion on the WHO global priority pathogens list. In this study we characterized multiple Shigella isolates from Malawi with whole genome sequence analysis, identifying the acquirable fluoroquinolone resistance determinant qnrS1.

Original language	English
Article number	000532
Pages (from-to)	1-6
Number of pages	6
Journal	Microbial Genomics
Volume	7
Issue number	5
DOIs	https://doi.org/10.1099/mgen.0.000532
Publication status	Published - 2021

Bibliographical note

Copyright the Author(s) 2021. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

AMR
FQR
Shigella
WGS

Access to Document

10.1099/mgen.0.000532

Publisher version (open access)Final published version, 0.98 MBLicence: CC BY

Cite this

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title = "Whole genome sequence analysis of Shigella from Malawi identifies fluoroquinolone resistance",

abstract = "Increasing antimicrobial resistance and limited alternative treatments have led to fluoroquinolone-resistant Shigella strain inclusion on the WHO global priority pathogens list. In this study we characterized multiple Shigella isolates from Malawi with whole genome sequence analysis, identifying the acquirable fluoroquinolone resistance determinant qnrS1.",

keywords = "AMR, FQR, Shigella, WGS",

author = "Stenhouse, {George E.} and Jere, {Khuzwayo C.} and Chikondi Peno and Bengtsson, {Rebecca J.} and End Chinyama and Jonathan Mandolo and Amy Cain and Miren Iturriza-G{\'o}mara and Naor Bar-Zeev and Cunliffe, {Nigel A.} and Jennifer Cornick and Baker, {Kate S.}",

note = "Copyright the Author(s) 2021. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2021",

doi = "10.1099/mgen.0.000532",

language = "English",

volume = "7",

pages = "1--6",

journal = "Microbial Genomics",

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publisher = "Microbiology Society",

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TY - JOUR

T1 - Whole genome sequence analysis of Shigella from Malawi identifies fluoroquinolone resistance

AU - Stenhouse, George E.

AU - Jere, Khuzwayo C.

AU - Peno, Chikondi

AU - Bengtsson, Rebecca J.

AU - Chinyama, End

AU - Mandolo, Jonathan

AU - Cain, Amy

AU - Iturriza-Gómara, Miren

AU - Bar-Zeev, Naor

AU - Cunliffe, Nigel A.

AU - Cornick, Jennifer

AU - Baker, Kate S.

N1 - Copyright the Author(s) 2021. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2021

Y1 - 2021

N2 - Increasing antimicrobial resistance and limited alternative treatments have led to fluoroquinolone-resistant Shigella strain inclusion on the WHO global priority pathogens list. In this study we characterized multiple Shigella isolates from Malawi with whole genome sequence analysis, identifying the acquirable fluoroquinolone resistance determinant qnrS1.

AB - Increasing antimicrobial resistance and limited alternative treatments have led to fluoroquinolone-resistant Shigella strain inclusion on the WHO global priority pathogens list. In this study we characterized multiple Shigella isolates from Malawi with whole genome sequence analysis, identifying the acquirable fluoroquinolone resistance determinant qnrS1.

KW - AMR

KW - FQR

KW - Shigella

KW - WGS

UR - http://www.scopus.com/inward/record.url?scp=85105503559&partnerID=8YFLogxK

UR - http://purl.org/au-research/grants/arc/DE180100929

U2 - 10.1099/mgen.0.000532

DO - 10.1099/mgen.0.000532

M3 - Article

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AN - SCOPUS:85105503559

SN - 2057-5858

VL - 7

SP - 1

EP - 6

JO - Microbial Genomics

JF - Microbial Genomics

IS - 5

M1 - 000532

ER -

Whole genome sequence analysis of Shigella from Malawi identifies fluoroquinolone resistance

Abstract

Bibliographical note

Keywords

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Stronger Together: Understanding Antibiotic Synergy on a Molecular Level

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Whole genome sequence analysis of Shigella from Malawi identifies fluoroquinolone resistance

Abstract

Bibliographical note

Keywords

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Stronger Together: Understanding Antibiotic Synergy on a Molecular Level

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