Whole-genome sequence of Schistosoma haematobium

Neil D. Young, Aaron R. Jex, Bo Li, Shiping Liu, Linfeng Yang, Zijun Xiong, Yingrui Li, Cinzia Cantacessi, Ross S. Hall, Xun Xu, Fangyuan Chen, Xuan Wu, Adhemar Zerlotini, Guilherme Oliveira, Andreas Hofmann, Guojie Zhang, Xiaodong Fang, Yi Kang, Bronwyn E. Campbell, Alex LoukasShoba Ranganathan, David Rollinson, Gabriel Rinaldi, Paul J. Brindley, Huanming Yang, Jun Wang, Jian Wang, Robin B. Gasser*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

297 Citations (Scopus)

Abstract

Schistosomiasis is a neglected tropical disease caused by blood flukes (genus Schistosoma; schistosomes) and affecting 200 million people worldwide. No vaccines are available, and treatment relies on one drug, praziquantel. Schistosoma haematobium has come into the spotlight as a major cause of urogenital disease, as an agent linked to bladder cancer and as a predisposing factor for HIV/AIDS. The parasite is transmitted to humans from freshwater snails. Worms dwell in blood vessels and release eggs that become embedded in the bladder wall to elicit chronic immune-mediated disease and induce squamous cell carcinoma. Here we sequenced the 385-Mb genome of S. haematobium using Illumina-based technology at 74-fold coverage and compared it to sequences from related parasites. We included genome annotation based on function, gene ontology, networking and pathway mapping. This genome now provides an unprecedented resource for many fundamental research areas and shows great promise for the design of new disease interventions.

Original languageEnglish
Pages (from-to)221-225
Number of pages5
JournalNature Genetics
Volume44
Issue number2
DOIs
Publication statusPublished - Feb 2012

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