Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

Theresa V. Strong; Danilo A. Tagle; John M. Valdes; Lawrence W. Elmer; Karina Boehm; Manju Swaroop; Kevin W. Kaatz; Francis S. Collins; Roger L. Albin

doi:10.1038/ng1193-259

Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

Theresa V. Strong, Danilo A. Tagle, John M. Valdes, Lawrence W. Elmer, Karina Boehm, Manju Swaroop, Kevin W. Kaatz, Francis S. Collins^*, Roger L. Albin

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

351 Citations (Scopus)

Abstract

We have used RNA in situ hybridization to study the regional expression of the Huntington's disease gene (HD) and its rat homologue in brain and selected nonneural tissues. The HD transcript was expressed throughout the brain in both rat and human, especially in the neurons of the dentate gyrus and pyramidal neurons of the hippocampal formation, cerebellar granule cell layer, cerebellar Purkinje cells and pontine nuclei. Other brain areas expressed lower levels of the HD transcript without pronounced regional differences. Neuronal expression predominated over glial expression in all regions. HD mRNA was also expressed in colon, liver, pancreas and testes. The regional specificity of neuropathology in HD, which is most prominent in the basal ganglia, thus cannot be accounted for by the pattern of expression of HD.

Original language	English
Pages (from-to)	259-265
Number of pages	7
Journal	Nature Genetics
Volume	5
Issue number	3
DOIs	https://doi.org/10.1038/ng1193-259
Publication status	Published - 1993

Access to Document

10.1038/ng1193-259

Cite this

@article{4760e6199c71460ab68d6574e4a02ed6,

title = "Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues",

abstract = "We have used RNA in situ hybridization to study the regional expression of the Huntington's disease gene (HD) and its rat homologue in brain and selected nonneural tissues. The HD transcript was expressed throughout the brain in both rat and human, especially in the neurons of the dentate gyrus and pyramidal neurons of the hippocampal formation, cerebellar granule cell layer, cerebellar Purkinje cells and pontine nuclei. Other brain areas expressed lower levels of the HD transcript without pronounced regional differences. Neuronal expression predominated over glial expression in all regions. HD mRNA was also expressed in colon, liver, pancreas and testes. The regional specificity of neuropathology in HD, which is most prominent in the basal ganglia, thus cannot be accounted for by the pattern of expression of HD.",

author = "Strong, {Theresa V.} and Tagle, {Danilo A.} and Valdes, {John M.} and Elmer, {Lawrence W.} and Karina Boehm and Manju Swaroop and Kaatz, {Kevin W.} and Collins, {Francis S.} and Albin, {Roger L.}",

year = "1993",

doi = "10.1038/ng1193-259",

language = "English",

volume = "5",

pages = "259--265",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Springer, Springer Nature",

number = "3",

}

TY - JOUR

T1 - Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

AU - Strong, Theresa V.

AU - Tagle, Danilo A.

AU - Valdes, John M.

AU - Elmer, Lawrence W.

AU - Boehm, Karina

AU - Swaroop, Manju

AU - Kaatz, Kevin W.

AU - Collins, Francis S.

AU - Albin, Roger L.

PY - 1993

Y1 - 1993

N2 - We have used RNA in situ hybridization to study the regional expression of the Huntington's disease gene (HD) and its rat homologue in brain and selected nonneural tissues. The HD transcript was expressed throughout the brain in both rat and human, especially in the neurons of the dentate gyrus and pyramidal neurons of the hippocampal formation, cerebellar granule cell layer, cerebellar Purkinje cells and pontine nuclei. Other brain areas expressed lower levels of the HD transcript without pronounced regional differences. Neuronal expression predominated over glial expression in all regions. HD mRNA was also expressed in colon, liver, pancreas and testes. The regional specificity of neuropathology in HD, which is most prominent in the basal ganglia, thus cannot be accounted for by the pattern of expression of HD.

AB - We have used RNA in situ hybridization to study the regional expression of the Huntington's disease gene (HD) and its rat homologue in brain and selected nonneural tissues. The HD transcript was expressed throughout the brain in both rat and human, especially in the neurons of the dentate gyrus and pyramidal neurons of the hippocampal formation, cerebellar granule cell layer, cerebellar Purkinje cells and pontine nuclei. Other brain areas expressed lower levels of the HD transcript without pronounced regional differences. Neuronal expression predominated over glial expression in all regions. HD mRNA was also expressed in colon, liver, pancreas and testes. The regional specificity of neuropathology in HD, which is most prominent in the basal ganglia, thus cannot be accounted for by the pattern of expression of HD.

UR - http://www.scopus.com/inward/record.url?scp=0027432418&partnerID=8YFLogxK

U2 - 10.1038/ng1193-259

DO - 10.1038/ng1193-259

M3 - Article

C2 - 8275091

AN - SCOPUS:0027432418

SN - 1061-4036

VL - 5

SP - 259

EP - 265

JO - Nature Genetics

JF - Nature Genetics

IS - 3

ER -

Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

Abstract

Access to Document

Other files and links

Fingerprint

Cite this