Widespread expression of the human and rat Huntington's disease gene in brain and nonneural tissues

Theresa V. Strong, Danilo A. Tagle, John M. Valdes, Lawrence W. Elmer, Karina Boehm, Manju Swaroop, Kevin W. Kaatz, Francis S. Collins*, Roger L. Albin

*Corresponding author for this work

Research output: Contribution to journalArticle

310 Citations (Scopus)

Abstract

We have used RNA in situ hybridization to study the regional expression of the Huntington's disease gene (HD) and its rat homologue in brain and selected nonneural tissues. The HD transcript was expressed throughout the brain in both rat and human, especially in the neurons of the dentate gyrus and pyramidal neurons of the hippocampal formation, cerebellar granule cell layer, cerebellar Purkinje cells and pontine nuclei. Other brain areas expressed lower levels of the HD transcript without pronounced regional differences. Neuronal expression predominated over glial expression in all regions. HD mRNA was also expressed in colon, liver, pancreas and testes. The regional specificity of neuropathology in HD, which is most prominent in the basal ganglia, thus cannot be accounted for by the pattern of expression of HD.

Original languageEnglish
Pages (from-to)259-265
Number of pages7
JournalNature Genetics
Volume5
Issue number3
DOIs
Publication statusPublished - 1993

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