TY - JOUR
T1 - Within-session variability as quality control for oscillometry in health and disease
AU - Harkness, Louise M.
AU - Patel, Kieran
AU - Sanai, Farid
AU - Rutting, Sandra
AU - Cottee, Alice M.
AU - Farah, Claude S.
AU - Schoeffel, Robin E.
AU - King, Gregory G.
AU - Thamrin, Cindy
N1 - Copyright the Author(s) 2021. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.
PY - 2021/10
Y1 - 2021/10
N2 - Oscillometry is increasingly adopted in respiratory clinics, but many recommendations regarding measurement settings and quality control remain subjective. The aim of this study was to investigate the optimal number of measurements and acceptable within-session coefficient of variation (CoV) in health, asthma and COPD. 15 healthy, 15 asthma and 15 COPD adult participants were recruited. Eight consecutive 30-s measurements were made using an oscillometry device, from which resistance at 5 Hz (Rrs5) was examined. The effect of progressively including a greater number of measurements on Rrs5 and its within-session CoV was investigated. Data were analysed using one-way repeated-measures ANOVA with Bonferroni post hoc test. The CoV(Rrs5) of the first three measurements was 6.7±4.7%, 9.7±5.7% and 12.6±11.2% in healthy, asthma and COPD participants, respectively. Both mean Rrs5 and CoV(Rrs5) were not statistically different when progressively including four to eight measurements. Selecting the three closest Rrs5 values over an increasing number of measurements progressively decreased the CoV(Rrs5). In order for ≥95% of participants to fall within a target CoV(Rrs5) of 10%, four or more, five and six measurements were needed in health, asthma and COPD, respectively. Within-session variability of oscillometry is increased in disease. Furthermore, the higher number of measurements required to achieve a set target for asthma and COPD patients may not be practical in a clinical setting. Provided technical acceptability of measurements is established, i.e. by removing artefacts and outliers, then a CoV of 10% is a marker of quality in most patients, but we suggest higher CoVs up to 15-20% should still be reportable.
AB - Oscillometry is increasingly adopted in respiratory clinics, but many recommendations regarding measurement settings and quality control remain subjective. The aim of this study was to investigate the optimal number of measurements and acceptable within-session coefficient of variation (CoV) in health, asthma and COPD. 15 healthy, 15 asthma and 15 COPD adult participants were recruited. Eight consecutive 30-s measurements were made using an oscillometry device, from which resistance at 5 Hz (Rrs5) was examined. The effect of progressively including a greater number of measurements on Rrs5 and its within-session CoV was investigated. Data were analysed using one-way repeated-measures ANOVA with Bonferroni post hoc test. The CoV(Rrs5) of the first three measurements was 6.7±4.7%, 9.7±5.7% and 12.6±11.2% in healthy, asthma and COPD participants, respectively. Both mean Rrs5 and CoV(Rrs5) were not statistically different when progressively including four to eight measurements. Selecting the three closest Rrs5 values over an increasing number of measurements progressively decreased the CoV(Rrs5). In order for ≥95% of participants to fall within a target CoV(Rrs5) of 10%, four or more, five and six measurements were needed in health, asthma and COPD, respectively. Within-session variability of oscillometry is increased in disease. Furthermore, the higher number of measurements required to achieve a set target for asthma and COPD patients may not be practical in a clinical setting. Provided technical acceptability of measurements is established, i.e. by removing artefacts and outliers, then a CoV of 10% is a marker of quality in most patients, but we suggest higher CoVs up to 15-20% should still be reportable.
UR - http://www.scopus.com/inward/record.url?scp=85118251028&partnerID=8YFLogxK
U2 - 10.1183/23120541.00074-2021
DO - 10.1183/23120541.00074-2021
M3 - Article
C2 - 34651039
AN - SCOPUS:85118251028
SN - 2312-0541
VL - 7
SP - 1
EP - 8
JO - ERJ Open Research
JF - ERJ Open Research
IS - 4
M1 - 00074-2021
ER -