Wnt signaling proteins associate with the nuclear pore complex

Implications for cancer

Manisha Sharma*, Michael Johnson, Mariana Brocardo, Cara Jamieson, Beric R. Henderson

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Citations (Scopus)

Abstract

Several components of the Wnt signaling pathway have in recent years been linked to the nuclear pore complex. β-catenin, the primary transducer of Wnt signals from the plasma membrane to the nucleus, has been shown to transiently associate with different FG-repeat containing nucleoporins (Nups) and to translocate bidirectionally through pores of the nuclear envelope in a manner independent of classical transport receptors and the Ran GTPase. Two key regulators of β-catenin, IQGAP1 and APC, have also been reported to bind specific Nups or to locate at the nuclear pore complex. The interaction between these Wnt signaling proteins and different Nups may have functional implications beyond nuclear transport in cellular processes that include mitotic regulation, centrosome positioning and cell migration, nuclear envelope assembly/disassembly, and the DNA replication checkpoint. The broad implications of interactions between Wnt signaling proteins and Nups will be discussed in the context of cancer.

Original languageEnglish
Title of host publicationCancer Biology and the Nuclear Envelope
Subtitle of host publicationRecent Advances May Elucidate Past Paradoxes
EditorsEric C. Schirmer, Jose I. de las Heras
Place of PublicationNew York
PublisherSpringer, Springer Nature
Pages353-372
Number of pages20
ISBN (Electronic)9781489980328
ISBN (Print)9781489980311
DOIs
Publication statusPublished - 2014

Publication series

NameAdvances in Experimental Medicine and Biology
Volume773
ISSN (Print)0065-2598

Keywords

  • APC
  • Cancer
  • Centrosome
  • IQGAP1
  • Nuclear envelope
  • Wnt signaling
  • nucleus
  • β-catenin

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  • Cite this

    Sharma, M., Johnson, M., Brocardo, M., Jamieson, C., & Henderson, B. R. (2014). Wnt signaling proteins associate with the nuclear pore complex: Implications for cancer. In E. C. Schirmer, & J. I. de las Heras (Eds.), Cancer Biology and the Nuclear Envelope: Recent Advances May Elucidate Past Paradoxes (pp. 353-372). (Advances in Experimental Medicine and Biology; Vol. 773). New York: Springer, Springer Nature. https://doi.org/10.1007/978-1-4899-8032-8_16