Wnt signaling proteins associate with the nuclear pore complex: Implications for cancer

Manisha Sharma*, Michael Johnson, Mariana Brocardo, Cara Jamieson, Beric R. Henderson

*Corresponding author for this work

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    9 Citations (Scopus)

    Abstract

    Several components of the Wnt signaling pathway have in recent years been linked to the nuclear pore complex. β-catenin, the primary transducer of Wnt signals from the plasma membrane to the nucleus, has been shown to transiently associate with different FG-repeat containing nucleoporins (Nups) and to translocate bidirectionally through pores of the nuclear envelope in a manner independent of classical transport receptors and the Ran GTPase. Two key regulators of β-catenin, IQGAP1 and APC, have also been reported to bind specific Nups or to locate at the nuclear pore complex. The interaction between these Wnt signaling proteins and different Nups may have functional implications beyond nuclear transport in cellular processes that include mitotic regulation, centrosome positioning and cell migration, nuclear envelope assembly/disassembly, and the DNA replication checkpoint. The broad implications of interactions between Wnt signaling proteins and Nups will be discussed in the context of cancer.

    Original languageEnglish
    Title of host publicationCancer Biology and the Nuclear Envelope
    Subtitle of host publicationRecent Advances May Elucidate Past Paradoxes
    EditorsEric C. Schirmer, Jose I. de las Heras
    Place of PublicationNew York
    PublisherSpringer, Springer Nature
    Pages353-372
    Number of pages20
    ISBN (Electronic)9781489980328
    ISBN (Print)9781489980311
    DOIs
    Publication statusPublished - 2014

    Publication series

    NameAdvances in Experimental Medicine and Biology
    Volume773
    ISSN (Print)0065-2598

    Keywords

    • APC
    • Cancer
    • Centrosome
    • IQGAP1
    • Nuclear envelope
    • Wnt signaling
    • nucleus
    • β-catenin

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