Working memory, catecholamines and psychosis: Illustrative case

Objective: To briefly review the role of catecholamines in prefrontal functions and working memory as illustrated by a case study. Method: The work of Goldman-Rakic and Arnsten on working memory is briefly reviewed. A case study that illustrates catecholamine functions in an autistic disorder child, who suffered a prolonged psychosis, is described. Results: While the role of dopaminergic neurotransmission in working memory has been described, the present case also illustrates a role for a noradrenergic re-uptake inhibitor in treating the post-psychotic distractibility of a severely impaired early adolescent. Conclusion: The role of catecholamine neurotransmitters in the treatment of prefrontal symptoms should be further investigated.