World-Wide FINGERS Network: a global approach to risk reduction and prevention of dementia

Miia Kivipelto; Francesca Mangialasche; Heather M. Snyder; Ricardo Allegri; Sandrine Andrieu; Hidenori Arai; Laura Baker; Sylvie Belleville; Henry Brodaty; Sonia M. Brucki; Ismael Calandri; Paulo Caramelli; Christopher Chen; Howard Chertkow; Effie Chew; Seong H. Choi; Neerja Chowdhary; Lucía Crivelli; Rafael De La Torre; Yifeng Du; Tarun Dua; Mark Espeland; Howard H. Feldman; Maris Hartmanis; Tobias Hartmann; Megan Heffernan; Christiani J. Henry; Chang H. Hong; Krister Håkansson; Takeshi Iwatsubo; Jee H. Jeong; Gustavo Jimenez-Maggiora; Edward H. Koo; Lenore J. Launer; Jenni Lehtisalo; Francisco Lopera; Pablo Martínez-Lage; Ralph Martins; Lefkos Middleton; José L. Molinuevo; Manuel Montero-Odasso; So Y. Moon; Kristal Morales-Pérez; Ricardo Nitrini; Haakon B. Nygaard; Yoo K. Park; Markku Peltonen; Chengxuan Qiu; Yakeel T. Quiroz; Rema Raman; Naren Rao; Vijayalakshmi Ravindranath; Anna Rosenberg; Takashi Sakurai; Rosa M. Salinas; Philip Scheltens; Gustavo Sevlever; Hilkka Soininen; Ana L. Sosa; Claudia K. Suemoto; Mikel Tainta-Cuezva; Lina Velilla; Yongxiang Wang; Rachel Whitmer; Xin Xu; Lisa J. Bain; Alina Solomon; Tiia Ngandu; Maria C. Carrillo

doi:10.1002/alz.12123

World-Wide FINGERS Network: a global approach to risk reduction and prevention of dementia

Miia Kivipelto^*, Francesca Mangialasche, Heather M. Snyder, Ricardo Allegri, Sandrine Andrieu, Hidenori Arai, Laura Baker, Sylvie Belleville, Henry Brodaty, Sonia M. Brucki, Ismael Calandri, Paulo Caramelli, Christopher Chen, Howard Chertkow, Effie Chew, Seong H. Choi, Neerja Chowdhary, Lucía Crivelli, Rafael De La Torre, Yifeng DuTarun Dua, Mark Espeland, Howard H. Feldman, Maris Hartmanis, Tobias Hartmann, Megan Heffernan, Christiani J. Henry, Chang H. Hong, Krister Håkansson, Takeshi Iwatsubo, Jee H. Jeong, Gustavo Jimenez-Maggiora, Edward H. Koo, Lenore J. Launer, Jenni Lehtisalo, Francisco Lopera, Pablo Martínez-Lage, Ralph Martins, Lefkos Middleton, José L. Molinuevo, Manuel Montero-Odasso, So Y. Moon, Kristal Morales-Pérez, Ricardo Nitrini, Haakon B. Nygaard, Yoo K. Park, Markku Peltonen, Chengxuan Qiu, Yakeel T. Quiroz, Rema Raman, Naren Rao, Vijayalakshmi Ravindranath, Anna Rosenberg, Takashi Sakurai, Rosa M. Salinas, Philip Scheltens, Gustavo Sevlever, Hilkka Soininen, Ana L. Sosa, Claudia K. Suemoto, Mikel Tainta-Cuezva, Lina Velilla, Yongxiang Wang, Rachel Whitmer, Xin Xu, Lisa J. Bain, Alina Solomon, Tiia Ngandu, Maria C. Carrillo

^*Corresponding author for this work

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Abstract

Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline—from at-risk asymptomatic states to early symptomatic stages—in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.

Original language	English
Pages (from-to)	1078-1094
Number of pages	17
Journal	Alzheimer's and Dementia
Volume	16
Issue number	7
DOIs	https://doi.org/10.1002/alz.12123
Publication status	Published - 1 Jul 2020

Bibliographical note

Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Alzheimer's disease
cognitive impairment
dementia
lifestyle
multidomain intervention
prevention
randomized controlled trial
World-Wide FINGERS

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10.1002/alz.12123Licence: CC BY-NC-ND

Publisher version (open access)Final published version, 764 KBLicence: CC BY-NC-ND

Cite this

Kivipelto, M., Mangialasche, F., Snyder, H. M., Allegri, R., Andrieu, S., Arai, H., Baker, L., Belleville, S., Brodaty, H., Brucki, S. M., Calandri, I., Caramelli, P., Chen, C., Chertkow, H., Chew, E., Choi, S. H., Chowdhary, N., Crivelli, L., Torre, R. D. L., ... Carrillo, M. C. (2020). World-Wide FINGERS Network: a global approach to risk reduction and prevention of dementia. Alzheimer's and Dementia, 16(7), 1078-1094. https://doi.org/10.1002/alz.12123

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abstract = "Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline—from at-risk asymptomatic states to early symptomatic stages—in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.",

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author = "Miia Kivipelto and Francesca Mangialasche and Snyder, {Heather M.} and Ricardo Allegri and Sandrine Andrieu and Hidenori Arai and Laura Baker and Sylvie Belleville and Henry Brodaty and Brucki, {Sonia M.} and Ismael Calandri and Paulo Caramelli and Christopher Chen and Howard Chertkow and Effie Chew and Choi, {Seong H.} and Neerja Chowdhary and Luc{\'i}a Crivelli and Torre, {Rafael De La} and Yifeng Du and Tarun Dua and Mark Espeland and Feldman, {Howard H.} and Maris Hartmanis and Tobias Hartmann and Megan Heffernan and Henry, {Christiani J.} and Hong, {Chang H.} and Krister H{\aa}kansson and Takeshi Iwatsubo and Jeong, {Jee H.} and Gustavo Jimenez-Maggiora and Koo, {Edward H.} and Launer, {Lenore J.} and Jenni Lehtisalo and Francisco Lopera and Pablo Mart{\'i}nez-Lage and Ralph Martins and Lefkos Middleton and Molinuevo, {Jos{\'e} L.} and Manuel Montero-Odasso and Moon, {So Y.} and Kristal Morales-P{\'e}rez and Ricardo Nitrini and Nygaard, {Haakon B.} and Park, {Yoo K.} and Markku Peltonen and Chengxuan Qiu and Quiroz, {Yakeel T.} and Rema Raman and Naren Rao and Vijayalakshmi Ravindranath and Anna Rosenberg and Takashi Sakurai and Salinas, {Rosa M.} and Philip Scheltens and Gustavo Sevlever and Hilkka Soininen and Sosa, {Ana L.} and Suemoto, {Claudia K.} and Mikel Tainta-Cuezva and Lina Velilla and Yongxiang Wang and Rachel Whitmer and Xin Xu and Bain, {Lisa J.} and Alina Solomon and Tiia Ngandu and Carrillo, {Maria C.}",

note = "Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2020",

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Kivipelto, M, Mangialasche, F, Snyder, HM, Allegri, R, Andrieu, S, Arai, H, Baker, L, Belleville, S, Brodaty, H, Brucki, SM, Calandri, I, Caramelli, P, Chen, C, Chertkow, H, Chew, E, Choi, SH, Chowdhary, N, Crivelli, L, Torre, RDL, Du, Y, Dua, T, Espeland, M, Feldman, HH, Hartmanis, M, Hartmann, T, Heffernan, M, Henry, CJ, Hong, CH, Håkansson, K, Iwatsubo, T, Jeong, JH, Jimenez-Maggiora, G, Koo, EH, Launer, LJ, Lehtisalo, J, Lopera, F, Martínez-Lage, P, Martins, R, Middleton, L, Molinuevo, JL, Montero-Odasso, M, Moon, SY, Morales-Pérez, K, Nitrini, R, Nygaard, HB, Park, YK, Peltonen, M, Qiu, C, Quiroz, YT, Raman, R, Rao, N, Ravindranath, V, Rosenberg, A, Sakurai, T, Salinas, RM, Scheltens, P, Sevlever, G, Soininen, H, Sosa, AL, Suemoto, CK, Tainta-Cuezva, M, Velilla, L, Wang, Y, Whitmer, R, Xu, X, Bain, LJ, Solomon, A, Ngandu, T & Carrillo, MC 2020, 'World-Wide FINGERS Network: a global approach to risk reduction and prevention of dementia', Alzheimer's and Dementia, vol. 16, no. 7, pp. 1078-1094. https://doi.org/10.1002/alz.12123

TY - JOUR

T1 - World-Wide FINGERS Network

T2 - a global approach to risk reduction and prevention of dementia

AU - Kivipelto, Miia

AU - Mangialasche, Francesca

AU - Snyder, Heather M.

AU - Allegri, Ricardo

AU - Andrieu, Sandrine

AU - Arai, Hidenori

AU - Baker, Laura

AU - Belleville, Sylvie

AU - Brodaty, Henry

AU - Brucki, Sonia M.

AU - Calandri, Ismael

AU - Caramelli, Paulo

AU - Chen, Christopher

AU - Chertkow, Howard

AU - Chew, Effie

AU - Choi, Seong H.

AU - Chowdhary, Neerja

AU - Crivelli, Lucía

AU - Torre, Rafael De La

AU - Du, Yifeng

AU - Dua, Tarun

AU - Espeland, Mark

AU - Feldman, Howard H.

AU - Hartmanis, Maris

AU - Hartmann, Tobias

AU - Heffernan, Megan

AU - Henry, Christiani J.

AU - Hong, Chang H.

AU - Håkansson, Krister

AU - Iwatsubo, Takeshi

AU - Jeong, Jee H.

AU - Jimenez-Maggiora, Gustavo

AU - Koo, Edward H.

AU - Launer, Lenore J.

AU - Lehtisalo, Jenni

AU - Lopera, Francisco

AU - Martínez-Lage, Pablo

AU - Martins, Ralph

AU - Middleton, Lefkos

AU - Molinuevo, José L.

AU - Montero-Odasso, Manuel

AU - Moon, So Y.

AU - Morales-Pérez, Kristal

AU - Nitrini, Ricardo

AU - Nygaard, Haakon B.

AU - Park, Yoo K.

AU - Peltonen, Markku

AU - Qiu, Chengxuan

AU - Quiroz, Yakeel T.

AU - Raman, Rema

AU - Rao, Naren

AU - Ravindranath, Vijayalakshmi

AU - Rosenberg, Anna

AU - Sakurai, Takashi

AU - Salinas, Rosa M.

AU - Scheltens, Philip

AU - Sevlever, Gustavo

AU - Soininen, Hilkka

AU - Sosa, Ana L.

AU - Suemoto, Claudia K.

AU - Tainta-Cuezva, Mikel

AU - Velilla, Lina

AU - Wang, Yongxiang

AU - Whitmer, Rachel

AU - Xu, Xin

AU - Bain, Lisa J.

AU - Solomon, Alina

AU - Ngandu, Tiia

AU - Carrillo, Maria C.

N1 - Copyright the Author(s) 2020. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2020/7/1

Y1 - 2020/7/1

N2 - Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline—from at-risk asymptomatic states to early symptomatic stages—in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.

AB - Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer's disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline—from at-risk asymptomatic states to early symptomatic stages—in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.

KW - Alzheimer's disease

KW - cognitive impairment

KW - dementia

KW - lifestyle

KW - multidomain intervention

KW - prevention

KW - randomized controlled trial

KW - World-Wide FINGERS

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UR - http://purl.org/au-research/grants/nhmrc/1095097

U2 - 10.1002/alz.12123

DO - 10.1002/alz.12123

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AN - SCOPUS:85087445765

SN - 1552-5260

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EP - 1094

JO - Alzheimer's and Dementia

JF - Alzheimer's and Dementia

IS - 7

ER -

World-Wide FINGERS Network: a global approach to risk reduction and prevention of dementia

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