Abstract
In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these liposomes on HCT 116 cells including the levels of singlet oxygen, mitochondrial membrane potential, cell apoptosis/necrosis and the expression of apoptosis-related proteins. The results corroborated that synchronous action of PDT and X-ray radiation enhance the generation of cytotoxic reactive oxygen species produced from the engineered liposomes, causing mitochondrial dysfunction and increasing the levels of apoptosis.
Original language | English |
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Article number | 87 |
Number of pages | 13 |
Journal | Journal of Nanobiotechnology |
Volume | 18 |
Issue number | 1 |
DOIs | |
Publication status | Published - 10 Jun 2020 |
Bibliographical note
Copyright © 2020 The Author(s). Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.Keywords
- Gold nanoparticles
- Liposome
- Mitochondria-targeted
- Photodynamic therapy
- X-ray