X-ray induced photodynamic therapy (PDT) with a mitochondria-targeted liposome delivery system

Xuefan Gu, Chao Shen, Hua Li, Ewa M. Goldys*, Wei Deng

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

In this study, we constructed multifunctional liposomes with preferentially mitochondria-targeted feature and gold nanoparticles-assisted synergistic photodynamic therapy. We systemically investigated the in vitro X-ray triggered PDT effect of these liposomes on HCT 116 cells including the levels of singlet oxygen, mitochondrial membrane potential, cell apoptosis/necrosis and the expression of apoptosis-related proteins. The results corroborated that synchronous action of PDT and X-ray radiation enhance the generation of cytotoxic reactive oxygen species produced from the engineered liposomes, causing mitochondrial dysfunction and increasing the levels of apoptosis.

Original languageEnglish
Article number87
Number of pages13
JournalJournal of Nanobiotechnology
Volume18
Issue number1
DOIs
Publication statusPublished - 10 Jun 2020

Bibliographical note

Copyright © 2020 The Author(s). Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Gold nanoparticles
  • Liposome
  • Mitochondria-targeted
  • Photodynamic therapy
  • X-ray

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