Yeast as a model for studying Alzheimer's disease

Prashant Bharadwaj, Ralph Martins, Ian Macreadie*

*Corresponding author for this work

Research output: Contribution to journalReview article

41 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by acute cognitive decline. The AD brain is featured by extracellular senile amyloid plaques, intraneuronal neurofibrillary tangles and extensive neuronal cell loss in specific regions of the brain associated with memory. The exact mechanism of neuronal cell dysfunction leading to the memory loss in AD is poorly understood. A number of studies have indicated that yeast is a suitable model system to decipher the molecular mechanisms involved in a variety of neurodegenerative disorders caused by pathological protein misfolding and deposition. Here, the knowledge from various studies that have utilized a yeast model to study the mechanism of pathways involved in AD pathogenesis is summarized.

Original languageEnglish
Pages (from-to)961-969
Number of pages9
JournalFEMS Yeast Research
Volume10
Issue number8
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Amyloid Aβ
  • Neurotoxicity
  • Tau phosphorylation
  • Toxic protein oligomerization

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