ZIF-8 labelled a new electrochemical aptasensor based on PEI-PrGO/AuNWs for DON detection

Jia Wu, Baoshan He*, Yuling Wang, Renyong Zhao, Yurong Zhang*, Chunqi Bai, Min Wei, Huali Jin, Wenjie Ren , Zhiguang Suo, Yiwei Xu

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


In this work, a novel ultrasensitive aptasensor for deoxynivalenol (DON) detection based on the polyethyleneimine-functionalised porous reduced graphene oxide loaded gold nanowires (PEI-PrGO/AuNWs) and methylene blue (MB)-labelled zeolitic imidazolate framework-8 (ZIF-8) signal amplification strategy was proposed. PEI-PrGO/AuNWs with large surface area and excellent conductivity were used as modification materials on bare gold electrodes, which could increase the combining of complementary strand (cDNA) on the electrode substrate and accelerate the electron transfer efficiency. Furthermore, a novel electrochemical signal probe was synthesized using streptavidin-modified zeolitic imidazolate framework-8 (ZIF-8/SA) as a carrier loaded with MB and reverse complementary chain (sDNA). In the presence of DON, the signal probe was introduced to the electrode surface by Watson-Crick base pairing after specific binding of DON to the aptamer (Apt). As expected, under the optimal conditions, the DON concentration was linearly related to the peak current generated by the prepared aptasensor, and the measured data were combined with theoretical calculations to obtain a detection limit of 2.23 × 10−9 mg/mL.

Original languageEnglish
Article number125257
Pages (from-to)1-10
Number of pages10
Early online date30 Sept 2023
Publication statusPublished - 15 Jan 2024


  • Deoxynivalenol
  • Electrochemical aptasensor
  • PEI-PrGO/AuNWs
  • ZIF-8


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