Projects per year
Personal profile
Research interests
We now know that sugars attached to proteins and lipids on every cell (glycans) are intricately involved in bacterial and viral infection, the immune responses (both innate and acquired), all cancers, lung disease, brain function, fertilisation, cardiovascular disease and a multitude of other cellular mechanisms in human and all other species. My objective is to increase the scientific research activity in this field so that beneficial improvements to our biological understanding, and ultimately treatment, of health and disease can be achieved. To implement my objective, I have spent the last almost 30 years or so (with some time out to rear three children) applying my knowledge and leadership skills to achieve this implementation.
Biography
Prof Nicki Packer has had an extensive and varied career in biochemical research in both Chemistry and Biological Sciences. She was part of the team that established the Australian Proteome Analysis Facility (APAF) and co-founded Proteome Systems Limited, an Australian biotechnology company in which her group developed a platform of glycoanalytical technology and informatics tools. She is now Distinguished Professor of Glycoproteomics, Deputy Director of the MQ Biomolecular Discovery Research Centre and Academic Lead of APAF at Macquarie University, Sydney, Australia. She is a Chief Investigator in the ARC Centre of Excellence in Nanoscale Biophotonics and in the ARC Centre of Excellence in Synthetic Biology. She has gained international and national profile by linking glycomics with the proteomics and bioinformatics approaches to biological functional research. Her research interests are now in the structure, function, informatics and application of glycans and their conjugates as molecular markers, particularly in their role in cancer, therapeutics and microbial infection. Nicki has published extensively on glycomics research and works closely with industry.
Education/Academic qualification
Biochemistry, PhD, University of Sydney
1 Jan 1973 → 31 Dec 1977
Award Date: 31 Mar 1978
External positions
Principal Research Leader, Institute for Glycomics
1 Jan 2017 → 31 Dec 2021
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Collaborations and top research areas from the last five years
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A Prelude towards transforming adenoid cystic carcinoma into an immune hot tumour: Phase II
Chakraborty, R. (Primary Chief Investigator), Packer, N. (Chief Investigator), Shannon, K. (Chief Investigator), Rizos, H. (Associate Investigator), Lee, J. (Associate Investigator), Nasiri, N. (Associate Investigator), Dawes, J. (Associate Investigator), Tay, A. (Associate Investigator), Surya, V. (Associate Investigator), Chien, A. (Associate Investigator) & Liu, F. (Associate Investigator)
1/01/25 → 30/06/29
Project: Research
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A Prelude towards transforming adenoid cystic carcinoma into an immune hot tumour
Chakraborty, R. (Primary Chief Investigator), Packer, N. (Chief Investigator), Shannon, K. (Chief Investigator), Surya, V. (Associate Investigator), Lee, J. (Associate Investigator), Tay, A. (Associate Investigator), Rizos, H. (Associate Investigator), Nasiri, N. (Associate Investigator) & Dawes, J. (Associate Investigator)
1/01/25 → 30/06/26
Project: Research
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JDRF (BHDI led): Deep milk: comprehensive multi-omics to resolve the role of human breastmilk in type 1 diabetes risk
Burugupalli, S. (Chief Investigator), Hamilton-Williams, E. (Chief Investigator), Harrison, L. C. (Chief Investigator), Oakey, H. (Chief Investigator), Penno, M. (Chief Investigator), Thomson, R. (Chief Investigator), Wentworth, J. (Chief Investigator), Huynh, D. (Chief Investigator), Meikle, P. J. (Chief Investigator), Packer, N. (Primary Chief Investigator), Paul, S. (Chief Investigator) & George, A. (Chief Investigator)
2/08/24 → 31/12/25
Project: Research
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IDEAS: Metformin, gut epithelium and microbiome in the prevention of colorectal cancer
Packer, N. (Primary Chief Investigator), Molloy, M. (Chief Investigator), Hewawasam Gamage, H. (Chief Investigator), Paulsen, I. (Associate Investigator), Engel, A. (Associate Investigator) & El-Omar, E. (Associate Investigator)
1/07/23 → 30/06/26
Project: Research
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NHMRC Ideas led by UoM: Reversing Neurofibrosis: A New Way to Treat Type-2 Diabetes
Dodd, G. (Chief Investigator), Ling, C.-C. (Chief Investigator), Moh, E. (Primary Chief Investigator), Daglas, M. (Chief Investigator), Boskovic, Z. (Chief Investigator), Sumithran, K. (Associate Investigator), Cho, E. (Associate Investigator), Rose, A. (Associate Investigator) & Packer, N. (Associate Investigator)
1/01/23 → 31/12/26
Project: Research
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Immunological and pathobiological characteristics of a novel live Salmonella Typhimurium-vectored Campylobacter vaccine candidate for layer chickens
Mcdonald, J. B., Gan, E., Cain, J., Thoduka, S. G., Lee, J., Wade, B., Mauri, M., Cuccui, J., Wren, B. W., Packer, N. H., Londrigan, S. L., Fritzlar, S., Mohotti, S., Underwood, G. J., Andrews, D. M., Van, T. T. H. & Moore, R. J., 2025, In: Frontiers in veterinary science. 12, p. 1518231 19 p., 1518231.Research output: Contribution to journal › Article › peer-review
Open AccessFile27 Downloads (Pure) -
Inhibition of chondroitin sulphate-degrading enzyme Chondroitinase ABC by dextran sulphate
Dalal, S., Pathak, R., Moh, E. X. S. & Packer, N. H., Feb 2025, In: Glycoconjugate Journal. 42, 1, p. 53-59 7 p.Research output: Contribution to journal › Article › peer-review
Open AccessFile35 Downloads (Pure) -
Lectin-enabled glycan signature of small extracellular vesicles by surface-enhanced Raman spectroscopy
Zhang, W., Moh, E. S. X., Wu, M., Packer, N. H. & Wang, Y., 7 Dec 2025, In: Analyst. 150, 23, p. 5274-5285 12 p.Research output: Contribution to journal › Article › peer-review
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Meeting report of the GlySpace alliance and GaLSIC symposium
Aoki-Kinoshita, K. F., Lisacek, F., Mazumder, R., Ranzinger, R., Tiemeyer, M., Yamada, I. & Packer, N. H., May 2025, In: Glycobiology. 35, 5, p. 1-2 2 p., cwaf019.Research output: Contribution to journal › Article
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TANGO2 binds crystallin alpha B and its loss causes desminopathy
Stentenbach, M., Hughes, L. A., Fagan, S. V., Payne, B., Rudler, D. L., Siira, S. J., McCubbin, T., Chopin, A., Perks, K. L., Ermer, J. A., Hendry, J., Er, T. S., Balasubramaniam, S., Eliades, J. A., Hool, L. C., Packer, N. H., Moh, E. S. X., Padman, B. S., Rackham, O. & Filipovska, A., 6 Jun 2025, In: Nature Communications. 16, 1, p. 1-17 17 p., 5261 .Research output: Contribution to journal › Article › peer-review
Open AccessFile16 Downloads (Pure)